The 78,000-square-foot Krishna P. Singh Center for Nanotechnology at the University of Pennsylvania, Philadelphia, was designed by New York-based architects Marion Weiss and Michael Manfredi, Weiss/Manfredi, to house the school’s work in the field of nanotechnology. The building’s signature feature is a crystalline façade that was created by combining matching, but offset acid-etched and silk-screened lites of glass in insulating glass units (IGUs). The facility’s 18,000 square feet of glazing features five different pattern configurations, offering abundant natural daylight while reducing solar heat gain and glare. The unique glass works with pleated insulated metal panels to create a uniform shadow effect that encompasses the entire building envelope. Each IGU has an interior lite with a silk-screened pattern, and an exterior lite with an acid-etched pattern that is laminated with a lite of high-performance low-E glass. The project is expected to earn LEED Gold certification from the U.S. Green Building Council.